This review discusses the ozonolysis of natural rubber, highlighting its historical significance in understanding rubber structure and the chemical reactions involved, including the formation of ozonides and other degradation products. It emphasizes the impact of ozone on rubber integrity and outlines the role of antiozonants in preventing degradation, alongside presenting critical experimental findings on the effectiveness of various antiozonants in rubber formulations.Ozonolysis remains crucial for understanding natural rubber's molecular structure and assessing ozone degradation effects. The reaction of ozone with natural rubber leads to chain scission and various oxidative degradation products. Ozone concentrations in the troposphere have notably increased, impacting rubber degradation rates over the last two decades. Catalytic systems can enhance ozone destruction efficiency above 99.9%, influenced by reactor conditions and ozone concentration. Antiozonants provide critical protection against ozone-induced degradation, with mechanisms including scavenging and protective film formation.