The increasing volume of waste rubber generated from end-of-life tyres has raised significant concerns regarding the safe and sustainable recycling and reuse of this material. A viable solution is to incorporate waste rubber into asphalt mixtures, which contributes to recycling waste tyres and promotes the sustainability and resilience of pavement infrastructure. In recent years, Crumb Rubber-Stone Mastic Asphalt (CR-SMA) mixtures have received considerable attention due to their remarkable performance. However, the feasibility of implementing CR-SMA in the field on a large scale requires further investigation. This paper aims to evaluate this matter by reviewing the mix design practices of CR-SMA, assessing the performance characteristics of CR-SMA, and identifying gaps and potential areas for improvement. The gaps related to various factors like aggregate gradation, compaction technique, processing temperature, CR grains size and their concentration, and binder content have been identified and discussed in the paper. In addition, the key performance characteristics of CR-SMA mixtures, including binder drain-down, moisture susceptibility, permanent deformation, and fatigue cracking, are evaluated.